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The plasma half-life of nitrofurantoin is approximately 20 minutes in adults with normal renal function.

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Recommended empirical regimens for acute uncomplicated cystitis by the 2010 update of the infectious disease society of america clinical practice guidelines include nitrofurantoin, trimethoprim-sulfamethoxazole tmp-smx , or fosfomycin as alternatives for first-line therapy box 4 .

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